Description
RFRP-1 is a mammalian ortholog of avian gonadotropin inhibitory hormone (GnIH). RFRP-1 and other RF-amide family peptides activate their own receptor, GPR147. RFRP-1 exhibits anorexigenic, anti-fertility, and anxiogenic activities. RFRP-1-secreting neurons are stress activated and inhibit the secretion of gonadotropin and gonadotropin-releasing hormone (GnRH). In vivo, this peptide inhibits reproductive behavior, decreases food intake, and increases anxiety behavior in an oxytocin-mediated manner.
References
Kovács A, László K, Gálosi R, et al. Microinjection of RFRP-1 in the central nucleus of amygdala decreases food intake in the rat. Brain Res Bull. 2012 Sep 1;88(6):589-95. PMID: 22691952.
Kaewwongse M, Takayanagi Y, Onaka T. Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats. J Neuroendocrinol. 2011 Jan;23(1):20-7. PMID: 21029217.
Clarke IJ, Qi Y, Puspita Sari I, et al. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front Neuroendocrinol. 2009 Aug;30(3):371-8. PMID: 19362107.
