Description
CastanospermineactsasaninhibitorofN-glycosylation,inhibitingO-GlcNAcase,resultinginimmunosuppressive,anti-inflammatory,andantiviralactivities.Inleukocytesandendothelialcells,castanosperminedecreasesexpressionofcellularadhesionmoleculesICAM-1,ICAM-2,L-selectin,LFA-1α,VLA-4,Mac-1,andCR4.Castanospermineinhibitsmetastasisofmelanomacellsthroughamechanismthatinvolvedinitialtumorcellarrest.Inothercellularmodels,castanospermineincreasessecretionofmisfoldedsecretoryproteinα1antitrypsinZ.Inanimalmodelsofarthritis,castanosperminedecreasesreleaseofinflammatoryMarkersintothesynovium,preventingthedevelopmentofarthritiswhengivenasapre-treatmentandinhibitingdiseaseprogressionwhengivenafteronset.AlterationofglycoproteinprocessingalsoinhibitsviralreplicationoftheMoloneymurineleukemiavirus.
References
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