Cefoperazoneisathirdgenerationβ-lactamcephalosporinantibiotic.Cefoperazoneexhibitsantibacterialefficacyagainstgrampositiveandgramnegativebacteria,inhibitingpenicillinbindingproteinstopreventpeptidoglycansynthesisandbacterialcellwallformation.CefoperazonealsoinhibitsmammalianmRNAsplicingandisoftengivenincombinationwiththeβ-lactamasesulbactam.
| CasNo. | 62893-19-0 |
|---|---|
| Purity | ≥98% |
| Formula | C25H27N9O8S2 |
| FormulaWt. | 645.47 |
| ChemicalName | (6R,7R)-7-[[(2R)-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)-carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azABIcyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| IUPACName | (6R,7R)-7-[[2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid |
| MeltingPoint | 169-171°C |
| Appearance | WhiteorAlmostWhiteCrystallinePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C1629InfoSheetPDF |
|---|
AukemaKG,ChohanKK,PlourdeGL,etal.Smallmoleculeinhibitorsofyeastpre-mRNAsplicing.ACSChemBiol.2009Sep18;4(9):759-68.PMID:19634919.
MohantyS,SinghalR,SoodS,etal.Comparativeinvitroactivityofbeta-lactam/beta-lactamaseinhibitorcombinationsagainstgramnegativebacteria.IndianJMedRes.2005Nov;122(5):425-8.PMID:16456257.
YotsujiA,MitsuyamaJ,HoriR,etal.Mechanismofactionofcephalosporinsandresistancecausedbydecreasedaffinityforpenicillin-bindingproteinsinBacteroidesfragilis.AntimicrobAgentsChemother.1988Dec;32(12):1848-53.PMID:3266730.
