Cefoperazoneisathirdgenerationβ-lactamcephalosporinantibiotic.Cefoperazoneexhibitsantibacterialefficacyagainstgrampositiveandgramnegativebacteria,inhibitingpenicillinbindingproteinstopreventpeptidoglycansynthesisandbacterialcellwallformation.CefoperazonealsoinhibitsmammalianmRNAsplicingandisoftengivenincombinationwiththeβ-lactamasesulbactam.
| CasNo. | 62893-20-3 |
|---|---|
| Purity | ≥98% |
| Formula | C25H26N9NaO8S2 |
| FormulaWt. | 667.65 |
| ChemicalName | (6R,7R)-7-[[(2R)-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)-carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azABIcyclo[4.2.0]oct-2-ene-2-carboxylicacidsodiumsalt |
| IUPACName | sodium;(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonym | Bioperazone;Cefazone;Cefobis;Cefoneg;Farecef;Novobiocyl;Perocef |
| MeltingPoint | 200-202°C |
| Solubility | Solubleinwaterto75mM. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C1630MSDSPDF |
|---|---|
| InfoSheet | C1630InfoSheetPDF |
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MohantyS,SinghalR,SoodS,etal.Comparativeinvitroactivityofbeta-lactam/beta-lactamaseinhibitorcombinationsagainstgramnegativebacteria.IndianJMedRes.2005Nov;122(5):425-8.PMID:16456257.
YotsujiA,MitsuyamaJ,HoriR,etal.Mechanismofactionofcephalosporinsandresistancecausedbydecreasedaffinityforpenicillin-bindingproteinsinBacteroidesfragilis.AntimicrobAgentsChemother.1988Dec;32(12):1848-53.PMID:3266730.
