Cefoperazone is a third generation β-lactam cephalosporin antibiotic. Cefoperazone exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefoperazone also inhibits mammalian mRNA splicing and is often given in combination with the β-lactamase sulbactam.
| Cas No. | 62893-20-3 |
|---|---|
| Purity | ≥98% |
| Formula | C25H26N9NaO8S2 |
| Formula Wt. | 667.65 |
| Chemical Name | (6R,7R)-7-[[(2R)-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)- carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3- [[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt |
| IUPAC Name | sodium;(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonym | Bioperazone; Cefazone; Cefobis; Cefoneg; Farecef; Novobiocyl; Perocef |
| Melting Point | 200-202°C |
| Solubility | Soluble in water to 75 mM. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | C1630 MSDS PDF |
|---|---|
| Info Sheet | C1630 Info Sheet PDF |
Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.
Mohanty S, Singhal R, Sood S, et al. Comparative in vitro activity of beta-lactam/beta-lactamase inhibitor combinations against gram negative bacteria. Indian J Med Res. 2005 Nov;122(5):425-8. PMID: 16456257.
Yotsuji A, Mitsuyama J, Hori R, et al. Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. PMID: 3266730.
