Cefotaxime is a third generation β-lactam cephalosporin antibiotic. Cefotaxime exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefotaxime is also mostly resistant to β-lactamase activity.
| Cas No. | 63527-52-6 |
|---|---|
| Purity | ≥91% |
| Formula | C16H17N5O7S2 |
| Formula Wt. | 455.47 |
| Chemical Name | (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-(2-amino-4- thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| IUPAC Name | (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| Synonym | Cefotaxime; 7-[2-(2-amino-4-thiazolyl)-2-methoxyimino- acetamido]-cephalosporanic acid |
| Solubility | Soluble in water. |
| Appearance | A white or almost white Crystal Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | C1632 MSDS PDF |
|---|---|
| Info Sheet | C1632 Info Sheet PDF |
Philpott-Howard J, Williams JD. Activity of cephalosporin antibiotics against Haemophilus influenzae. Scand J Infect Dis Suppl. 1983;39:109-11. PMID: 6606223.
LeFrock JL, Prince RA, Leff RD. Mechanism of action, antimicrobial activity, pharmacology, adverse effects, and clinical efficacy of cefotaxime. Pharmacotherapy. 1982 Jul-Aug;2(4):174-84. PMID: 6302641.
