Ceftazidimeisathirdgenerationβ-lactamcephalosporinantibiotic.Ceftazidimeexhibitsantibacterialefficacyagainstmostgrampositiveandsomegramnegativebacteria,inhibitingpenicillinbindingproteinstopreventpeptidoglycansynthesisandbacterialcellwallformation.
| CasNo. | 78439-06-2 |
|---|---|
| Purity | ≥97% |
| Formula | C22H22N6O7S2•5H2O |
| FormulaWt. | 635.65 |
| ChemicalName | 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azABIcyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinuminnersalt |
| IUPACName | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonym | GR-20263;Fortum |
| Solubility | Slightlysolubleinwater,360mg/L |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C1635MSDSPDF |
|---|---|
| InfoSheet | C1635InfoSheetPDF |
ChantratitaN,RhollDA,SimB,etal.Antimicrobialresistancetoceftazidimeinvolvinglossofpenicillin-bindingprotein3inBurkholderiapseudomallei.ProcNatlAcadSciUSA.2011Oct11;108(41):17165-70.PMID:21969582.
PhelpsDJ,CarltonDD,FarrellCA,etal.Affinityofcephalosporinsforbeta-lactamasesasafactorinantibacterialefficacy.AntimicrobAgentsChemother.1986May;29(5):845-8.PMID:3524432.
