Ceftazidime is a third generation β-lactam cephalosporin antibiotic. Ceftazidime exhibits antibacterial efficacy against most gram positive and some gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation.
| Cas No. | 78439-06-2 |
|---|---|
| Purity | ≥97% |
| Formula | C22H22N6O7S2 • 5H2O |
| Formula Wt. | 635.65 |
| Chemical Name | 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)- [(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum inner salt |
| IUPAC Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonym | GR-20263; Fortum |
| Solubility | Slightly soluble in water, 360 mg/L |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | C1635 MSDS PDF |
|---|---|
| Info Sheet | C1635 Info Sheet PDF |
Chantratita N, Rholl DA, Sim B, et al. Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17165-70. PMID: 21969582.
Phelps DJ, Carlton DD, Farrell CA, et al. Affinity of cephalosporins for beta-lactamases as a factor in antibacterial efficacy. Antimicrob Agents Chemother. 1986 May;29(5):845-8. PMID: 3524432.
