Ceftiofurisathirdgenerationβ-lactamantibacterialusedinlivestock.Likeothersimilarantibiotics,ceftiofurinhibitssynthesisofbacterialcellwallsbyinhibitingpenicillinbindingproteins.Ceftiofuralsodisplaysanti-inflammatoryactivity.Invivo,thiscompounddecreasesLPS-inducedexpressionofIL-1β,IL-6,andTNF-α,exhibitingpotentialinthetreatmentofendotoxemia.
| CasNo. | 104010-37-9 |
|---|---|
| Purity | ≥90% |
| Formula | C19H17N5O7S3•HCl |
| FormulaWt. | 560.02 |
| ChemicalName | 5-Thia-1-azABIcyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo-,(6R-(6alpha,7beta(Z)))- |
| IUPACName | sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(furan-2-carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonym | Excenel;Ceftiofurum;Vetranal |
| Solubility | Insolubleinwater |
| Appearance | Whitetooff-whitecrystallinepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C1620InfoSheetPDF |
|---|
LiX,ZhengW,MacheskyML,etal.Degradationkineticsandmechanismofantibioticceftiofurinrecycledwaterderivedfromabeeffarm.JAgricFoodChem.2011Sep28;59(18):10176-81.PMID:21863813.
CiX,LiH,SongY,etal.CeftiofurregulatesLPS-inducedproductionofcytokinesandimprovesLPS-inducedsurvivalrateinmice.Inflammation.2008Dec;31(6):422-7.PMID:18989766.
