Ceftiofur is a third generation β-lactam antibacterial used in livestock. Like other similar antibiotics, ceftiofur inhibits synthesis of bacterial cell walls by inhibiting penicillin binding proteins. Ceftiofur also displays anti-inflammatory activity. In vivo, this compound decreases LPS-induced expression of IL-1β, IL-6, and TNF-α, exhibiting potential in the treatment of endotoxemia.
| Cas No. | 104010-37-9 |
|---|---|
| Purity | ≥90% |
| Formula | C19H17N5O7S3 • HCl |
| Formula Wt. | 560.02 |
| Chemical Name | 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((2-furanylcarbonyl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))- |
| IUPAC Name | sodium;(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(furan-2-carbonylsulfanylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| Synonym | Excenel; Ceftiofurum; Vetranal |
| Solubility | Insoluble in water |
| Appearance | White to off-white crystalline powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C1620 Info Sheet PDF |
|---|
Li X, Zheng W, Machesky ML, et al. Degradation kinetics and mechanism of antibiotic ceftiofur in recycled water derived from a beef farm. J Agric Food Chem. 2011 Sep 28;59(18):10176-81. PMID: 21863813.
Ci X, Li H, Song Y, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31(6):422-7. PMID: 18989766.
