Description
Ceftriaxone is a third generation β-lactam cephalosporin antibiotic. Ceftriaxone exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding protein activity to prevent peptidoglycan synthesis and bacterial cell wall formation. Ceftriaxone is also neuroprotective. This compound displays cognition enhancing benefit, suppressing traumatic brain injury-induced brain edema and cognitive function deficits in animal models by decreasing autophagy and upregulating expression of glutamate transporter GLT-1; this also results in protection in animal models of Huntington’s disease and attenuates the development of dependence and abstinence-induced withdrawal in animal models of substance abuse.
References
Cui C, Cui Y, Gao J, et al. Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury. Neurol Sci. 2014 May;35(5):695-700. PMID: 24277205.
Sari Y, Prieto AL, Barton SJ, et al. Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease. J Biomed Sci. 2010 Jul 27;17:62. PMID: 20663216.
Rawls SM, Cavallo F, Capasso A, et al. The beta-lactam antibiotic ceftriaxone inhibits physical dependence and abstinence-induced withdrawal from cocaine, amphetamine, methamphetamine, and clorazepate in planarians. Eur J Pharmacol. 2008 Apr 28;584(2-3):278-84. PMID: 18342307.
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