Chloramphenicol is an antibiotic compound that binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Chloramphenicol exhibits antibacterial activity against Streptomyces.
| Cas No. | 56-75-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H12Cl2N2O5 |
| Formula Wt. | 323.13 |
| Chemical Name | Acetamide, 2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)- |
| IUPAC Name | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide |
| Synonym | Chloromyxin; Ophthochlor; Ophthocort. |
| Melting Point | 150.5-151.5°C |
| Solubility | Slightly soluble in water (2.5 mg/ml). Very soluble in methanol, ethanol, ethyl acetate, acetone. |
| Appearance | White or Yellowish White Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | C2844 MSDS PDF |
|---|---|
| Info Sheet | C2844 Info Sheet PDF |
Sheth A, Escobar-Alvarez S, Gardner J, et al. Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers. Cell Death Dis. 2014 Mar 27;5:e1152. PMID: 24675470.
Rajesh T, Song E, Lee BR, et al. Increased sensitivity to chloramphenicol by inactivation of manB in Streptomyces coelicolor. J Microbiol Biotechnol. 2012 Oct;22(10):1324-9. PMID: 23075781.
Wilson DN. On the specificity of antibiotics targeting the large ribosomal subunit. Ann N Y Acad Sci. 2011 Dec;1241:1-16. PMID: 22191523.
