Chloramphenicolisanantibioticcompoundthatbindsthe50Ssubunitofthebacterialribosome,suppressingmitochondrialproteintranslation;itinhibitspeptidyltransferase,preventingtranslocation.ChloramphenicolexhibitsantibacterialactivityagainstStreptomyces.
| CasNo. | 56-75-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H12Cl2N2O5 |
| FormulaWt. | 323.13 |
| ChemicalName | Acetamide,2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)- |
| IUPACName | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide |
| Synonym | Chloromyxin;Ophthochlor;Ophthocort. |
| MeltingPoint | 150.5-151.5°C |
| Solubility | Slightlysolubleinwater(2.5mg/ml).Verysolubleinmethanol,ethanol,ethylacetate,acetone. |
| Appearance | WhiteorYellowishWhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | C2844MSDSPDF |
|---|---|
| InfoSheet | C2844InfoSheetPDF |
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RajeshT,SongE,LeeBR,etal.IncreasedsensitivitytochloramphenicolbyinactivationofmanBinStreptomycescoelicolor.JMicrobiolBiotechnol.2012Oct;22(10):1324-9.PMID:23075781.
WilsonDN.Onthespecificityofantibioticstargetingthelargeribosomalsubunit.AnnNYAcadSci.2011Dec;1241:1-16.PMID:22191523.
