Description
Chlortetracycline is a tetracycline antibiotic that also exhibits antioxidative, anti-parasitic, and neuroprotective activities. Chlortetracycline binds the 30S subunit of the bacterial ribosome, inhibiting protein synthesis; it also displays antibacterial and antimalarial properties. Additionally, this compound acts as a radical scavenger. In vivo, chlortetracycline suppresses calpain activity and weakly antagonizes NMDA receptor activity and Ca2+ influx, protecting against cerebral ischemia.
References
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Jiang SX, Lertvorachon J, Hou ST, et al. Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia. J Biol Chem. 2005 Oct 7;280(40):33811-8. PMID: 16091365.
