ChromomycinA3isananthraquinonethatexhibitsantibacterialandanticancerchemotherapeuticactivity.ChromomycinA3bindsMg2+andZn2+ions,andthesecomplexesbindGCsequencesinnucleosomalDNA;thisinhibitsDNAgyrase,RNApolymerase,andDNAtranscription.ChromomycininhibitsgrowthofbacteriasuchasBacillus,inhibitsalcoholdehydrogenase,andsuppressestumorgrowthofbreastcancerxenograftsinanimalmodels.
| CasNo. | 7059-24-7 |
|---|---|
| Purity | ≥97% |
| Formula | C57H82O26 |
| FormulaWt. | 1183.2488 |
| IUPACName | [6-[[6-[4-[4-(5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-(3,4-dihydroxy-1-methoxy-2-oxopentyl)-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-(4-hydroxy-5-methoxy-6-methyloxan-2-yl)oxy-2-methyloxan-3-yl]acetate |
| MeltingPoint | 182-186°C |
| Appearance | YellowPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C2969InfoSheetPDF |
|---|
DeviPG,ChakrabortyPK,DasguptaD.InhibitionofaZn(II)-containingenzyme,alcoholdehydrogenase,byanticancerantibiotics,mithramycinandchromomycinA3.JBiolInorgChem.2009Mar;14(3):347-59.PMID:19034537.
MirMA,DasguptaD.AssociationoftheanticancerantibioticchromomycinA(3)withthenucleosome:roleofcorehistonetaildomainsinthebindingprocess.Biochemistry.2001Sep25;40(38):11578-85.PMID:11560508.
SimonH,WittigB,ZimmerC.Effectofnetropsin,distamycinAandchromomycinA3onthebindingandcleavagereactionofDNAgyrase.FEBSLett.1994Oct10;353(1):79-83.PMID:7926028.
InoueK,FujimotoS,OgawaM.Antitumorefficacyofseventeenanticancerdrugsinhumanbreastcancerxenograft(MX-1)transplantedinnudemice.CancerChemotherPharmacol.1983;10(3):182-6.PMID:6305523.
