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商品详细LKT/CITREOVIRIDIN A/C3576/5 mg
LKT/CITREOVIRIDIN A/C3576/5 mg
LKT/CITREOVIRIDIN A/C3576/5 mg
商品编号: C3576-5mg
品牌: lktlabs
市场价: ¥9300.00
美元价: 5580.00
产地: 美国(厂家直采)
公司:
产品分类: 临床研究
公司分类: clinical_research
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Citreoviridin A is a mycotoxin found in cereal and bread grains; it exhibits pro-oxidative, anticancer chemotherapeutic, antibacterial, antifungal, and antiviral activities. In vitro, citreoviridin A increases ROS levels and decreases glutathione, inducing oxidative stress, destabilizing the lysosome and mitochondria and causing DNA damage. Citreoviridin A inhibits the F1 subunit of F1F0 ATP synthase, inhibiting cell proliferation in a lung cancer xenograft model. Citreoviridin also increases phosphorylation of eIF2α, inducing the unfolded protein response and the inhibition of cell growth. In other cellular models, this compound increases TNF-α-induced cellular adhesion to monocytes, increases nuclear translocation of NF-κB, and increases expression of ICAM-1, VCAM-1, E-selectin, and MCP-1. Citreoviridin inhibits cellular growth in species of Bacillus and Candida and also inhibits replication of HIV-1.

Product Info

Cas No.

25425-12-1

Purity

≥95%

Formula

C23H30O6

Formula Wt.

402.48

IUPAC Name

6-[(1E,3E,5E,7E)-8-[(2S,3R,4R,5R)-3,4-dihydroxy-2,4,5-trimethyloxolan-2-yl]-7-methylocta-1,3,5,7-tetraenyl]-4-methoxy-5-methylpyran-2-one

Synonym

citreoviridin

Melting Point

110°C

Solubility

Insoluble in water. Soluble in ethanol, chloroform, dichloromethane, and DMSO (10 mg/mL).

Appearance

Orange-yellow powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

Info Sheet

C3576 Info Sheet PDF

References

Bai Y, Jiang LP, Liu XF, et al. The role of oxidative stress in citreoviridin-induced DNA damage in human liver-derived HepG2 cells. Environ Toxicol. 2013 Dec 6. [Epub ahead of print]. PMID: 24318808.

Wu YH, Hu CW, Chien CW, et al. Quantitative proteomic analysis of human lung tumor xenografts treated with the ectopic ATP synthase inhibitor citreoviridin. PLoS One. 2013 Aug 21;8(8):e70642. PMID: 23990911.

Hou H, Zhou R, Jia Q, et al. Citreoviridin enhances tumor necrosis factor-α-induced adhesion of human umbilical vein endothelial cells. Toxicol Ind Health. 2013 Mar 22. PMID: 23524880.

Chang HY, Huang HC, Huang TC, et al. Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response. Cancer Res. 2012 Sep 15;72(18):4696-706. PMID: 22822083.

Vieta I, Savarino A, Papa G, et al. In vitro inhibitory activity of citreoviridin against HIV-1 and an HIV-associated opportunist: Candida albicans. J Chemother. 1996 Oct;8(5):351-7. PMID: 8957714.

Sayood SF, Suh H, Wilcox CS, et al. Effect of citreoviridin and isocitreoviridin on beef heart mitochondrial ATPase. Arch Biochem Biophys. 1989 May 1;270(2):714-21. PMID: 2523213.

品牌介绍
LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供:癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的,为全球提供先端的药物研发试剂、试剂盒、委托合成,并为药物生产企业提供原料,最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。 试剂