Colistin is an antimicrobial peptide (AMP); it is a polymixin-family antibiotic initially produced by species of Bacillus. Colistin displays antibacterial efficacy against gram negative bacteria, interacting with the bacterial outer membrane, inducing the formation of pores. This peptide also inhibits NADH quinone oxidoreductase. Colistin is no longer commonly used due to associated neurotoxicity and nephrotoxicity.
| Cas No. | 1264-72-8 |
|---|---|
| Purity | Biological Potency: ≥19366 IU/mg |
| Formula | C45H85N13O10 • H2O4S |
| Formula Wt. | 1267.55 |
| IUPAC Name | N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-5-methylheptanamide |
| Synonym | Belcomycin; Colomycin syrup |
| Solubility | Soluble in water. |
| Appearance | White Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | C5647 Info Sheet PDF |
|---|
Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2014 Feb;67(2):147-51. PMID: 24169795.
Dai C, Zhang D, Gao R, et al. In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism. Environ Toxicol Pharmacol. 2013 Sep;36(2):659-66. PMID: 23892071.
Manning AJ, Kuehn MJ. Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol. 2011 Dec 1;11:258. PMID: 22133164.
