Colistinisanantimicrobialpeptide(AMP);itisapolymixin-familyantibioticinitiallyproducedbyspeciesofBacillus.Colistindisplaysantibacterialefficacyagainstgramnegativebacteria,interactingwiththebacterialoutermembrane,inducingtheformationofpores.ThispeptidealsoinhibitsNADHquinoneoxidoreductase.Colistinisnolongercommonlyusedduetoassociatedneurotoxicityandnephrotoxicity.
| CasNo. | 1264-72-8 |
|---|---|
| Purity | BiologicalPotency:≥19366IU/mg |
| Formula | C45H85N13O10•H2O4S |
| FormulaWt. | 1267.55 |
| IUPACName | N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-5-methylheptanamide |
| Synonym | Belcomycin;Colomycinsyrup |
| Solubility | Solubleinwater. |
| Appearance | WhitePowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C5647InfoSheetPDF |
|---|
DerisZZ,AkterJ,SivanesanS,etal.AsecondarymodeofactionofpolymyxinsagainstGram-negativebacteriainvolvestheinhibitionofNADH-quinoneoxidoreductaseactivity.JAntibiot(Tokyo).2014Feb;67(2):147-51.PMID:24169795.
DaiC,ZhangD,GaoR,etal.Invitrotoxicityofcolistinonprimarychickcortexneuronsanditspotentialmechanism.EnvironToxicolPharmacol.2013Sep;36(2):659-66.PMID:23892071.
ManningAJ,KuehnMJ.Contributionofbacterialoutermembranevesiclestoinnatebacterialdefense.BMCMicrobiol.2011Dec1;11:258.PMID:22133164.
