LKT/CORDYCEPIN/C5968/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/CORDYCEPIN/C5968/25 mg

LKT/CORDYCEPIN/C5968/25 mg

商品编号： C5968-25mg

品牌： lktlabs

市场价： ¥3280.00

美元价： 1968.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC5968

CasNo.73-03-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

CordycepinisoriginallyfoundinavarietyofspeciesofthefungusCordycepsanddisplaysanticancer,neuromodulatory,anti-inflammatory,anti-parasitic,andantiviralactivities.Cordycepininducesdouble-strandedDNAbreaksincancercellswithincorporatedintonucleicacidchainsasitisa3-deoxyanalogofadenosine.Additionally,cordycepinincreasesgenerationofreactiveoxygenspecies(ROS),increasescaspaseactivityandPARPcleavage,andactivatesAMPK,inducingcaspase-mediatedapoptosisincells.CordycepindecreasestheamplitudeofexcitatorypresynapticmembranepotentialsandindirectlyinhibitsAMPAreceptor-andNMDAreceptor-mediatedresponsesthroughinhibitionofpresynapticexcitatoryneurotransmitterrelease.Invitro,cordycepindecreasesproductionofNO,activationofNF-κB,andexpressionofiNOS,COX-2,andTNF-α.ThiscompounddisplaysantimicrobialactivityagainstLeishmaniaandalsoterminatesRNAchainsincellsinfectedwithpicornavirus.

ProductInfo

CasNo.	73-03-0
Purity	≥98%
Formula	C₁₀H₁₃N₅O₃
FormulaWt.	251.24
ChemicalName	3"-deoxyadenosine
IUPACName	(2R,3R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolan-3-ol
Solubility	Water
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	C5968MSDSPDF
InfoSheet	C5968InfoSheetPDF

References

YaoLH,HuangJN,LiCH,etal.Cordycepinsuppressesexcitatorysynaptictransmissioninrathippocampalslicesviaapresynapticmechanism.CNSNeurosciTher.2013Apr;19(4):216-21.PMID:23419191.

LeeHJ,BurgerP,VogelM,etal.ThenucleosideantagoNISTcordycepincausesDNAdoublestrandbreaksinbreastcancercells.InvestNewDrugs.2012Oct;30(5):1917-25.PMID:22821173.

JeongJW,JinCY,ParkC,etal.Inductionofapoptosisbycordycepinviareactiveoxygenspeciesgenerationinhumanleukemiacells.ToxicolInVitro.2011Jun;25(4):817-24.PMID:21310227.

WangZ,WangX,QuK,etal.BindingofcordycepinmonophosphatetoAMP-activatedproteinkinaseanditseffectonAMP-activatedproteinkinaseactivation.ChemBiolDrugDes.2010Oct;76(4):340-4.PMID:20738312.

KimHG,ShresthaB,LimSY,etal.Cordycepininhibitslipopolysaccharide-inducedinflammationbythesuppressionofNF-kappaBthroughAktandp38inhibitioninRAW264.7macrophagecells.EurJPharmacol.2006Sep18;545(2-3):192-9.PMID:16899239.

WatayaY,HiraokaO.3"-Deoxyinosineasananti-leishmanialagent:themetabolismandcytotoxiceffectsof3"-deoxyinosineinLeishmaniatropicapromastigotes.BiochemBiophysResCommun.1984Sep17;123(2):677-83.PMID:6487305.

PanicaliDL,NairCN.EffectofcordycepintriphosphateoninvitroRNAsynthesisbypicornaviruspolymerasecomplexes.JVirol.1978Jan;25(1):124-8.PMID:202731.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂