Description
Corydaline is an alkaloid compound originally found in Corydalis tubers. Corydaline exhibits gastrointestinal modulatory, antinociceptive, anti-allergic, and anti-parasitic activities. Corydaline is currently in clinical trials as a potential treatment for functional dyspepsia. In animal models, corydaline increases gastric emptying and small intestine transit speed and induces gastric relaxation. In other animal models, corydaline inhibits chemically-induced pain. Additionally, this compound may inhibit mast cell-dependent smooth muscle contraction of the aorta. Corydaline also exhibits nematocidal activity against species of Strongyloides.
References
Lee TH, Son M, Kim SY. Effects of corydaline from Corydalis tuber on gastric motor function in an animal model. Biol Pharm Bull. 2010;33(6):958-62. PMID: 20522959.
Wang C, Wang S, Fan G, et al. Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem. 2010 Mar;396(5):1731-40. PMID: 20101504.
Saito SY, Tanaka M, Matsunaga K, et al. The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber. Biol Pharm Bull. 2004 Aug;27(8):1270-4. PMID: 15305035.
Satou T, Koga M, Matsuhashi R, et al. Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis. Vet Parasitol. 2002 Mar 1;104(2):131-8. PMID: 1180933.
