LKT/CURCUMIN/C8069/5 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/CURCUMIN/C8069/5 g

LKT/CURCUMIN/C8069/5 g

商品编号： C8069-5g

品牌： lktlabs

市场价： ¥760.00

美元价： 456.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC8069

CasNo.458-37-7

Purity≥97%curcuminoidcontent

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Curcuministheactivecomponentofturmeric,amemberofthegingerfamily.Curcuminisadiarylheptanoid;itdisplaysawidevarietyofhealthbenefits,includingantioxidative,anticancerchemotherapeutic,antifungal,antibiotic,andatheroscleroticprophylacticactivities.Inananimalmodelofrunning-inducedoxidativedamage,curcumindecreasesNADPH-oxidasemRNAandhydrogenperoxidelevels,decreasingoxidativestress.CurcuminincreaseslevelsofAPOBEC1,increasingbeneficialApoB-48anddecreasingharmfulApoB-100,facilitatingincreasedclearanceoflipidparticlesfromplasmainvitro.Incellularmodelsofcancer,curcuminactivatesmammaliansterile20-likekinase1(MST1),activatingJNKandinducingapoptosis.Incellularmodelsofglioma,curcumindownregulatesexpressionofsonichedgehog(Shh),Smo,GLI1,cyclinD1,andBcl-2,inhibitingproliferationandmigrationandincreasingapoptosis;inrelatedanimalmodels,curcumindecreasestumorvolumeandprolongssurvival.InananimalmodelofAlzheimer’sdiseaseutilizingtheMorriswatermaze,curcuminrescuescognitivedeficitsbyinhibitingcollapsingresponsemediatorprotein2(CRMP2)andprotectingagainstamyloid-β(Aβ)-inducedhippocampaldamage.ThiscompoundinhibitsfMLP-andLPS-inducedsuppressionofneutrophilapoptosisbypreventingactivationofNF-κBanddecreasingproductionofpro-inflammatorymediatorssuchasIL-6,IL-8,MIP-1α,andMIP-1β.Curcuminalsodisplaysantibacterialandantifungalactivities,inhibitingcellwallbiosynthesisofCandidaalbicansinvitro.

ProductInfo

CasNo.	458-37-7
Purity	≥97%curcuminoidcontent
Formula	C₂₁H₂₀O₆
FormulaWt.	368.38
ChemicalName	(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptADIene-3,5-dione
IUPACName	(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Synonym	Turmericyellow
MeltingPoint	183°C
Solubility	Insolubleinwater.Solubleinethanol(10mg/mL),DMSO(74mg/mL),chloroform,acetone,DMF.Solublein0.1MNaOHto3mg/mL-donotstoremorethan12hours.
Appearance	Orange-yellowpowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	C8069MSDSPDF
InfoSheet	C8069InfoSheetPDF
Brochures	CurcuminFlyer
	NaturalProductsBooklet
	HedgehogSignalingFlyer

References

KawanishiN,KatoK,TakahashiM,etal.Curcuminattenuatesoxidativestressfollowingdownhillrunning-inducedmuscledamage.BiochemBiophysResCommun.2013Nov22;441(3):573-8.PMID:24184481.

DuWZ,FengY,WangXF,etal.CurcuminSuppressesMalignantGliomaCellsGrowthandInducesApoptosisbyInhibitionofSHH/GLI1SignalingPathwayinVitroandVivo.CNSNeurosciTher.2013Dec;19(12):926-36.PMID:24165291.

TianN,LiX,LuoY,etal.CurcuminregulatesthemetabolismoflowdensitylipoproteinsbyimprovingtheC-to-URNAeditingefficiencyofapolipoproteinBinprimaryrathepatocytes.MolMedRep.2013Oct24.[Epubaheadofprint].PMID:24173373.

WangY,YinH,LiJ,etal.Ameliorationofβ-amyloid-inducedcognitivedysfunctionandhippocampalaxondegenerationbycurcuminisassociatedwithsuppressionofCRMP-2hyperphosphorylation.NeurosciLett.2013Oct21.[Epubaheadofprint].PMID:24157857.

AntoineF,SimardJC,GirardD.Curcumininhibitsagent-inducedhumanneutrophilfunctionsinvitroandlipopolysaccharide-inducedneutrophilicinfiltrationinvivo.IntImmunopharmacol.2013Oct21.[Epubaheadofprint].PMID:24157330.

GunesH,GulenD,MutluR,etal.Antibacterialeffectsofcurcumin:aninvitrominimuminhibitoryconcentrationstudy.ToxicolIndHealth.2013Oct21.[Epubaheadofprint].PMID:24097361.

KumarA,DhamgayeS,MauryaIK,etal.CurcumintargetscellwallintegrityviacalcineurinmediatedsignalinginCandidaalbicans.AntimicrobAgentsChemother.2013Oct21.[Epubaheadofprint].PMID:24145527.

YuT,JiJ,GuoYL.MST1activationbycurcuminmediatesJNKactivation,Foxo3anucleartranslocationandapoptosisinmelanomacells.BiochemBiophysResCommun.2013Oct14.[Epubaheadofprint].PMID:24134840.

NarayananN,NargiD,RandolphC,etal.LiposomeencapsulationofcurcuminandresveratrolincombinationreducesprostatecancerincidenceinPTENknockoutmice.IntJCancer.2009Feb6;125(1):1-8.PMID:19326431.

PerryMC,DemeuleM,ReginaA,etal.Curcumininhibitstumorgrowthandangiogenesisinglioblastomaxenografts.MolNutrFoodRes.2010Aug;54(8):1192-1201.PMID:20087857.

MartinRC,AiyerHS,MalikD,LiY.Effectonpro-inflammatoryandantioxidantgenesandbioavailabledistributionofwholeturmericvscurcumin:similarrootbutdifferenteffects.FoodChemToxicol.2012Feb;50(2):227-231.PMID:22079310.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂