Description
CyanopeptolinsarecytotoxicserineproteaseinhibitorsthatwasinitiallyproducedbyspeciesofcyanobacteriaMicrocystis.Thesepeptidesinhibitchymotrypsin,trypsin,plasmin,andelastase.Cyanopeptolinsmayalsoexhibitsomeantibacterialactivityagainstgrampositiveandgramnegativebacteria.
References
Silva-StenicoME,RigonatoJ,LealMG,etal.Non-ribosomalhalogenatedproteaseinhibitorsfromcyanobacterialisolatesasattractivedrugtargets.CurrMedChem.2012;19(30):5205-13.PMID:22934766.
GademannK,PortmannC,BlomJF,etal.Multipletoxinproductioninthecyanobacteriummicrocystis:isolationofthetoxicproteaseinhibitorcyanopeptolin1020.JNatProd.2010May28;73(5):980-4.PMID:20405925.
ChoiH,OhSK,YihW,etal.CyanopeptolineCB071:acyclicdepsipeptideisolatedfromthefreshwatercyanobacteriumAphanocapsasp.ChemPharmBull(Tokyo).2008Aug;56(8):1191-3.PMID:18670126.
vonElertE,ObererL,MerkelP,etal.Cyanopeptolin954,achlorine-containingchymotrypsininhibitorofMicrocystisaeruginosaNIVACya43.JNatProd.2005Sep;68(9):1324-7.PMID:16180807.
NeumannU,CamposV,CantareroS,etal.Co-occurrenceofnon-toxic(cyanopeptolin)andtoxic(microcystin)peptidesinabloomofMicrocystissp.fromaChileanlake.SystApplMicrobiol.2000Jun;23(2):191-7.PMID:10930070.