Cyclocytidine is a pyrimidine nucleoside analog that inhibits DNA synthesis; it exhibits antiviral and anticancer chemotherapeutic activities. Cyclocytidine induces degranulation of granular tubules in research models. This compound inhibits proliferation of herpes simplex virus (HSV-1) and cytomegalovirus (CMV) in vitro. Previously, cyclocytidine has been used to treat some leukemias, but has since largely been replaced in clinical use.
| Cas No. | 10212-25-6 |
|---|---|
| Purity | ≥98% |
| Formula | C9H11N3O4 • HCl |
| Formula Wt. | 261.66 |
| Chemical Name | 2,2'-Anhydro-1-β-D-arabinofuranosylcytosine hydrochloride |
| IUPAC Name | (2R,3R,3aR,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydrofuro[1,2][1,3]oxazolo[3,4-a]pyrimidin-3-ol;hydrochloride |
| Synonym | Ancitabine hydrochloride; O-2,2'-Cyclocytidine monohydrochloride |
| Melting Point | 269-270°C |
| Solubility | Soluble in water, micro-soluble alcohol |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | C9677 MSDS PDF |
|---|---|
| Info Sheet | C9677 Info Sheet PDF |
Thomopoulos GN, Garrett JR, Proctor GB. Ultrastructural histochemical studies of secretory granule replenishment in rat submandibular granular tubules after cyclocytidine-induced secretion. J Submicrosc Cytol Pathol. 2002 Jul;34(3):279-89. PMID: 12408361.
Chen Z, Song J, Chen K. Anti-herpes simplex virus action of combined therapy with cyclocytidine and ganciclovir. Zhonghua Yan Ke Za Zhi. 1996 Jan;32(1):25-8. PMID: 8758385.
Nakamura K, Eizuru Y, Kumura K, et al. Antiviral effect of antileukemic drugs N4-behenoyl-1-beta-D-arabinofuranosylcytosine (BH-AC) and 2,2'-anhydro-1-beta-D-arabinofuranosylcytosine (cyclo-C) against human cytomegalovirus. J Med Virol. 1990 Jun;31(2):141-7. PMID: 1696958.
Movassaghi N, Higgins G, Pyesmany A, et al. Evaluation of cyclocytidine in reinduction and maintenance therapy of children with acute nonlymphocytic leukemia previously treated with cytosine arabinoside: a report from Children's Cancer Study Group. Med Pediatr Oncol. 1984;12(5):352-6. PMID: 6208468.
