CyclosporinBisaderivativeofcyclosporinAthatexhibitssignificantlylessimmunosuppressiveactivity.CyclosporinBdisplaysantiviralproperties,inhibitingentryofhepatitisBintohepatocytes.CyclosporinBalsoinhibitsRANKL-inducedTRAPphosphataseactivity,inducingapoptosisinosteoclasts.
| CasNo. | 63775-95-1 |
|---|---|
| Purity | ≥95% |
| Formula | C61H109N11O12 |
| FormulaWt. | 1188.59 |
| ChemicalName | Ala2-cyclosporine |
| IUPACName | (3S,6S,9S,12S,15R,18S,21S,24S,30S,33R)-33-[(E)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28,30-decamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undeconeInChI:InChI=1S/C61H109N11O12/c1-25-26-27-39(14)51(74)50-55(78)64-41(16)56(79)66(18)32-47(73)67(19)43(28-33(2)3)54(77)65-48(37(10)11)60(83)68(20)44(29-34(4)5)53(76)62-40(15)52(75)63-42(17)57(80)69(21)45(30-35(6)7)58(81)70(22)46(31-36(8)9)59(82)71(23)49(38(12)13)61(84)72(50)24/h45-26,33-46,48-51,74H,27-32H2,1-24H3,(H,62,76)(H,63,75)(H,64,78)(H,65,77)/b26-25+/t39?,40-,41+,42+,43+,44+,45+,46+,48+,49+,50-,51?/m1/s1 |
| MeltingPoint | 149-152°C |
| Solubility | Solubleinmethanol,ethanolandacetone. |
| Appearance | Amorphouswhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C9615InfoSheetPDF |
|---|
IwamotoM,WatashiK,TsukudaS,etal.EvaluationandidentificationofhepatitisBvirusentryinhibitorsusingHepG2cellsoverexpressingamembranetransporterNTCP.BiochemBiophysResCommun.2014Jan17;443(3):808-13.PMID:24342612.
IgarashiK,HirotaniH,WooJT,etal.CyclosporineAandFK506induceosteoclastapoptosisinmousebonemarrowcellcultures.Bone.2004Jul;35(1):47-56.PMID:15207740.
