Description
Cyproconazole is a triazole fungicide/pesticide with broad spectrum antifungal activity. Like many azole fungicides, cyproconazole likely inhibits 14-α demethylase, inhibiting ergosterol production and fungal cell wall synthesis. Additionally, cyproconazole may inhibit aromatase. Cyproconazole may exhibit carcinogenic activity in vivo, altering hepatic cell proliferation, serum cholesterol, and hepatic retinoic acid levels in an androgen receptor-dependent manner. Additionally, cyproconazole also acts as a nonspecific inhibitor of voltage-gated Ca2+ channels in PC12 neurons, modulating intracellular Ca2+ levels.
References
Heusinkveld HJ, Molendijk J, van den Berg M, et al. Azole fungicides disturb intracellular Ca2+ in an additive manner in dopaminergic PC12 cells. Toxicol Sci. 2013 Aug;134(2):374-81. PMID: 23708404.
Hester S, Moore T, Padgett WT, et al. The hepatocarcinogenic conazoles: cyproconazole, epoxiconazole, and propiconazole induce a common set of toxicological and transcriptional responses. Toxicol Sci. 2012 May;127(1):54-65. PMID: 22334560.
Peffer RC, Moggs JG, Pastoor T, et al. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicol Sci. 2007 Sep;99(1):315-25. PMID: 17557908.
