Spectinomycin is an aminocyclitol antibiotic initially produced by Streptomyces. Spectinomycin binds 16S rRNA of the 30S bacterial ribosome, inhibiting translocation and protein synthesis. Spectinomycin exhibits antibacterial activity and was originally used to treat gonorrhea, but has since been replaced by newer drugs.
| Cas No. | 22189-32-8 |
|---|---|
| Purity | ≥96% |
| Formula | C14H24N2O7 • 2HCl • 5H2O |
| Formula Wt. | 495.25 |
| Synonym | Spectam; Spectinomycin dihydrochloride; Stanilo |
| Melting Point | 205-207°C (dec) |
| Solubility | Soluble in water to 100 mM. methanol, propylene glycol, and formamid. DMSO to 99 mg/mL, PBS to 10 mg/mL. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | S6018 MSDS PDF |
|---|---|
| Info Sheet | S6018 Info Sheet PDF |
Ilina EN, Malakhova MV, Bodoev IN, et al. Mutation in ribosomal protein S5 leads to spectinomycin resistance in Neisseria gonorrhoeae. Front Microbiol. 2013 Jul 10;4:186. PMID: 23847609.
Kehrenberg C, Schwarz S. Mutations in 16S rRNA and ribosomal protein S5 associated with high-level spectinomycin resistance in Pasteurella multocida. Antimicrob Agents Chemother. 2007 Jun;51(6):2244-6. PMID: 17371823.
