Description
Spiramycinisamacrolideantibioticthatisclinicallyusedtotreattoxoplasmosisandothersofttissueinfections.SpiramycinexhibitsantibacterialefficacyagainstToxoplasma,inhibitingbacterialproteinsynthesis.Invitro,spiramycindecreaseslevelsofIL-10andTNF-α,andinvivo,itdecreasesToxoplasma-inducedbraincysts.
References
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ChewWK,SegarraI,AmbuS,etal.SignificantreductionofbraincystscausedbyToxoplasmagondiiaftertreatmentwithspiramycincoadmiNISTeredwithmetronidazoleinamousemodelofchronictoxoplasmosis.AntimicrobAgentsChemother.2012Apr;56(4):1762-8.PMID:22271863.