StaurosporineisanalkaloidinitiallyproducedbyStreptomycesthatinhibitsPKCandotherproteinkinases.StaurosporineisaprecursorinthesynthesisofkinaseinhibitorsK252candPKC412.Thiscompoundexhibitsanticancer,anti-parasitic,andanti-protozoanactivities.Staurosporineinducesapoptosisinhepatocarcinomacellsbydecreasinglevelsofp38MAPK,pERK,andDNAmethyltransferase3B(DNMT3B)andincreasinglevelsofpJNK.StaurosporinealsocausescelldeathinTrypanosoma.ThiscompoundalsoinhibitsmammalianRNAsplicing.
| CasNo. | 62996-74-1 |
|---|---|
| Purity | ≥98% |
| Formula | C28H26N4O3 |
| FormulaWt. | 466.5 |
| Synonym | AM-2282 |
| MeltingPoint | 237-239°C |
| Solubility | SolubleinDMSO(50mM),ethanol,ormethanol(2mg/mL).Insolubleinwater. |
| Appearance | YellowPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | S7600MSDSPDF |
|---|---|
| InfoSheet | S7600InfoSheetPDF |
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