Streptozocinisanitrosourea-aminosugarconjugateinitiallyproducedbyspeciesofStreptomycesthatexhibitspro-diabetic,antibacterial,andanticanceractivities.Streptozocinistoxictopancreaticisletβcellsandisoftenusedtoinducediabetes-likeconditionsinanimalmodels.Streptozocinhasalsobeenexaminedasapotentialtreatmentforcancersofβcells.
| CasNo. | 18883-66-4 |
|---|---|
| Purity | ≥98% |
| Formula | C8H15N3O7 |
| FormulaWt. | 265.22 |
| ChemicalName | 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucopyranose |
| IUPACName | 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]ureaInChI:InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1 |
| Synonym | Streptozotocin;NSC-85998;U-9889;Zanosar |
| MeltingPoint | 121°C(dec) |
| Solubility | Solubleinwater,ketonesandloweralcohols. |
| Appearance | PaleYellowCrystallinePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | S7870MSDSPDF |
|---|---|
| InfoSheet | S7870InfoSheetPDF |
RerupCC.Drugsproducingdiabetesthroughdamageoftheinsulinsecretingcells.PharmacolRev.1970Dec;22(4):485-518.PMID:4921840.
Murray-LyonIM,EddlestonAL,WilliamsR,etal.Treatmentofmultiple-hormone-producingmalignantislet-celltumourwithstreptozotocin.Lancet.1968Oct26;2(7574):895-8.PMID:4176152.
VavraJJ,DeboerC,DietzA,etal.Streptozotocin,anewantibacterialantibiotic.AntibiotAnnu.1959-1960;7:230-5.PMID:13841501.
