Quinacrineexhibitsanti-parasitic,anti-protozoan,anticancer,andanti-inflammatoryactivities.QuinacrinealterscellmembranepermeABIlityandisclinicallyusedtotreatinfectionsofGiardia.Incoloncancercells,quinacrineinducesapoptosis,activatesp53andp21,andinhibitstopoisomerase.Inothercellularmodels,quinacrinedecreasesTNF-α,IL-1β,andCCL21production,suppressesmigrationofdendriticcells,andinhibitsactivationofCD8+Tcells.
| CasNo. | 6151-30-0 |
|---|---|
| Purity | ≥97% |
| Formula | C23H30ClN3O•2HCl•2H2O |
| FormulaWt. | 508.92 |
| ChemicalName | N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,-4-pentanediaminedihydrochloridedihydrate |
| IUPACName | 4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrate;dihydrochloride |
| Synonym | Atebrinehydrochloride;RP-866;SN-390;Mepacrine |
| MeltingPoint | 248-250°C(dec) |
| Solubility | Solubleinhotwater.Slightlysolubleinethanol,methanolorwater.Insolubleinether,benzeneoracetone. |
| Appearance | Brightyellowpowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | Q8133MSDSPDF |
|---|---|
| InfoSheet | Q8133InfoSheetPDF |
MohapatraP,PreetR,DasD,etal.Quinacrine-mediatedautophagyandapoptosisincoloncancercellsisthroughap53-andp21-dependentmechanism.OncolRes.2012;20(2-3):81-91.PMID:23193914.
GorbachevAV,GasparianAV,GurovaKV,etal.QuinacrineinhibitstheepidermaldendriticcellmigrationinitiatingTcell-mediatedskininflammation.EurJImmunol.2007Aug;37(8):2257-67.PMID:17634953.
FasanmadeAA,OwuorED,EeRP,etal.Quinacrineinducescytochromec-dependentapoptoticsignalinginhumancervicalcarcinomacells.ArchPharmRes.2001Apr;24(2):126-35.PMID:11339632.
