Radicicol is an analog of benzoquinone ansamycin that inhibits HSP90, Src family kinases, and Raf. Radicicol exhibits neuroprotective, antibiotic, antifungal, anti-parasitic, and antimalarial activities. In Plasmodium, radicicol targets topoisomerase VI-B, inhibiting mitochondrial replication. Radicicol also increases survival and neurite outgrowth of neurons in chick embryos.
| Cas No. | 12772-57-5 |
|---|---|
| Purity | ≥96% |
| Formula | C18H17ClO6 |
| Formula Wt. | 364.78 |
| Chemical Name | 8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihyroxy-14- methyl-6H-oxireno[e][2]benzoxacyclotetradecin- 6,12(7H)-dione |
| Synonym | Monorden; Monorderne |
| Melting Point | 193.5°C |
| Solubility | Soluble in DMSO, methanol or ethanol. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | R0212 MSDS PDF |
|---|---|
| Info Sheet | R0212 Info Sheet PDF |
Chalapareddy S, Bhattacharyya MK, Mishra S, et al. Radicicol Confers Mid-Schizont Arrest by Inhibiting Mitochondrial Replication in Plasmodium falciparum. Antimicrob Agents Chemother. 2014 Aug;58(8):4341-4352. PMID: 24841259.
Gadelle D, Bocs C, Graille M, et al. Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol. Nucleic Acids Res. 2005 Apr 22;33(7):2310-7. PMID: 15849317.
Sano M, Yoshida M, Fukui S, et al. Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo. J Neurochem. 1999 Jun;72(6):2256-63. PMID: 10349833.
