LKT/RALOXIFENE HYDROCHLORIDE/R0243/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/RALOXIFENE HYDROCHLORIDE/R0243/500 mg

LKT/RALOXIFENE HYDROCHLORIDE/R0243/500 mg

商品编号： R0243-500mg

品牌： lktlabs

市场价： ¥4240.00

美元价： 2544.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDR0243

CasNo.82640-04-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Raloxifeneisaselectiveestrogenreceptormodulator(SERM)thatexhibitsagoNISTactivityinboneandantagonistactivityinuterineandbreasttissues.Raloxifeneisclinicallyusedtopreventosteoporosisinpost-menopausalwomenandtotreatER+breastcancer.Thiscompoundexhibitsanti-osteoporotic,anti-parasitic,neuromodulatory,andanticancerchemotherapeuticactivities.Raloxifenedecreasesfractureriskandenhancesbonestrengthinclinicalsettings.Invitroandinvivo,raloxifeneinhibitsgrowthofLeishmaniaandparasiticburden.Additionally,raloxifeneincreasesuptakeofglutamateandexpressionofGLT-1inastrocytes.Inanimalmodelsofbreastcancer,thiscompounddecreasesexpressionofEGFR,vasculardensity,andtumorgrowth.

ProductInfo

CasNo.	82640-04-8
Purity	≥98%
Formula	C₂₈H₂₇NO₄S•HCl
FormulaWt.	510.05
ChemicalName	[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanonehydrochloride
IUPACName	[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;hydrochloride
Synonym	Evista
MeltingPoint	258°C
Solubility	Veryslightlysolubleinwater.SolubleinDMSOat28mg/mL.
Appearance	YellowishCrystallinePowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	R0243MSDSPDF
InfoSheet	R0243InfoSheetPDF

References

KarkiP,WebbA,ZerguineA,etal.Mechanismofraloxifene-inducedupregulationofglutamatetransportersinratprimaryastrocytes.Glia.2014Aug;62(8):1270-83.PMID:24782323.

ReimãoJQ,MiguelDC,TaniwakiNN,etal.Antileishmanialactivityoftheestrogenreceptormodulatorraloxifene.PLoSNeglTropDis.2014May8;8(5):e2842.PMID:24810565.

GallantMA,BrownDM,HammondM,etal.Bonecell-independentbenefitsofraloxifeneontheskeleton:anovelmechanismforimprovingbonematerialproperties.Bone.2014Apr;61:191-200.PMID:24468719.

TaurinS,AllenKM,ScandlynMJ,etal.Raloxifenereducestriple-negativebreastcancertumorgrowthanddecreasesEGFRexpression.IntJOncol.2013Sep;43(3):785-92.PMID:23842642.

GizzoS,SaccardiC,PatrelliTS,etal.Updateonraloxifene:mechanismofaction,clinicalefficacy,adverseeffects,andcontraindications.ObstetGynecolSurv.2013Jun;68(6):467-81.PMID:23942473.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂