Reveromycin A is an osteoclast-targeting antibiotic compound that exhibits anti-resorptive and antifungal activities. In animal models of juvenile Paget’s disease, reveromycin A inhibits bone resorption and normalizes bone turnover and formation. Reveromycin A inhibits isoleucyl-tRNA synthase, preventing protein synthesis in osteoclasts; this induces apoptosis and prevents resorption in vivo. Additionally, reveromycin A inhibits bone metastasis by lung cancer cells.
| Cas No. | 134615-37-5 |
|---|---|
| Purity | ≥98% |
| Formula | C36H52O11 |
| Formula Wt. | 660.79 |
| Chemical Name | Butanedioic acid, mono(3-butyl-8-(9-carboxy-6- hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butadienyl)-9-methyl-1,7-dioxaspiro(5.5)undec-3-yl) ester |
| IUPAC Name | (2E,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoicacid |
| Melting Point | 95°C |
| Solubility | Soluble in DMF, DMSO, ethanol, ethyl acetate or methanol. |
| Appearance | Tan Lyophilisate |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | R1985 Info Sheet PDF |
|---|
Yabumoto T, Miyazawa K, Tabuchi M, et al. Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice. Am J Orthod Dentofacial Orthop. 2013 Sep;144(3):368-80. PMID: 23992809.
Hiraoka K, Zenmyo M, Watari K, et al. Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci. 2008 Aug;99(8):1595-602. PMID: 18754872.
Woo JT, Kawatani M, Kato M, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34. PMID: 16537392.
