ReveromycinAisanosteoclast-targetingantibioticcompoundthatexhibitsanti-resorptiveandantifungalactivities.InanimalmodelsofjuvenilePaget’sdisease,reveromycinAinhibitsboneresorptionandnormalizesboneturnoverandformation.ReveromycinAinhibitsisoleucyl-tRNAsynthase,preventingproteinsynthesisinosteoclasts;thisinducesapoptosisandpreventsresorptioninvivo.Additionally,reveromycinAinhibitsbonemetastasisbylungcancercells.
| CasNo. | 134615-37-5 |
|---|---|
| Purity | ≥98% |
| Formula | C36H52O11 |
| FormulaWt. | 660.79 |
| ChemicalName | Butanedioicacid,mono(3-butyl-8-(9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butADIenyl)-9-methyl-1,7-dioxaspiro(5.5)undec-3-yl)ester |
| IUPACName | (2E,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoicacid |
| MeltingPoint | 95°C |
| Solubility | SolubleinDMF,DMSO,ethanol,ethylacetateormethanol. |
| Appearance | TanLyophilisate |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R1985InfoSheetPDF |
|---|
YabumotoT,MiyazawaK,TabuchiM,etal.StABIlizationoftoothmovementbyadmiNISTrationofreveromycinAtoosteoprotegerin-deficientknockoutmice.AmJOrthodDentofacialOrthop.2013Sep;144(3):368-80.PMID:23992809.
HiraokaK,ZenmyoM,WatariK,etal.Inhibitionofboneandmusclemetastasesoflungcancercellsbyadecreaseinthenumberofmonocytes/macrophages.CancerSci.2008Aug;99(8):1595-602.PMID:18754872.
WooJT,KawataniM,KatoM,etal.ReveromycinA,anagentforosteoporosis,inhibitsboneresorptionbyinducingapoptosisspecificallyinosteoclasts.ProcNatlAcadSciUSA.2006Mar21;103(12):4729-34.PMID:16537392.
