Ricobendazoleisananti-parasiticnitroimidazolecompoundadmiNISTeredsubcutaneously,unlikemostnitroimidazoles.Ricobendazolebindsthecolchicinesiteoftubulin,inhibitingmicrotubulepolymerization.Ricobendazolealsoexhibitsanticanceractivity,potentiatingtheeffectsoftaxanesandinhibitingcellproliferationinbreastcancercells,non-smallcelllungcancer(NSCLC)cells,andmelanomacells.
| CasNo. | 54029-12-8 |
|---|---|
| Purity | ≥98% |
| Formula | C12H15N3O3S |
| FormulaWt. | 281.33 |
| ChemicalName | (5-propylsulfinyl)-1H-benzimidazol-2-yl)-methylestercarbamicacid |
| IUPACName | methylN-(6-propylsulfinyl-1H-benzimidazol-2-yl)carbamate |
| Synonym | (+-)-Albendazolesulfoxide;Albendazoleoxide |
| MeltingPoint | 226-228°C(dec) |
| Appearance | Whiteoryellowishwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R3310InfoSheetPDF |
|---|
LopesWD,CruzBC,SoaresVE,etal.Historicoftherapeuticefficacyofalbendazolsulphoxideadministeredindifferentroutes,dosagesandtreatmentschemes,againstTaeniasaginatacysticercusincattleexperimentallyinfected.ExpParasitol.2014Feb;137:14-20.PMID:24309372.
BelazKR,DenadaiM,AlmeidaAP,etal.EnantiomericresolutionofalbendazolesulfoxidebysemipreparativeHPLCandinvitrostudyofgrowthinhibitoryeffectsonhumancancercelllines.JPharmBiomedAnal.2012Jul;66:100-8.PMID:22487592.
