Rifamycin is an ansamycin antibiotic that exhibits antibacterial and anti-inflammatory activities. Rifamycin inhibits bacterial DNA-dependent RNA polymerase, preventing formation of the initiation complex in transcription and suppressing RNA synthesis. Rifamycin displays efficacy against Mycobacterium, Clostridium, and Enterobacter. This compound also decreases LPS-stimulated cytokine synthesis in macrophages and cytokine secretion from CD4+ T cells in cellular models.
| Cas No. | 14897-39-3 |
|---|---|
| Purity | ≥98% |
| Formula | C37H46NO12Na |
| Formula Wt. | 719.75 |
| Synonym | Rifamycin SV sodium salt; Rifamastene; Rifocin |
| Solubility | Soluble in water (pH7.2). |
| Appearance | Red Crystal Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | R3222 Info Sheet PDF |
|---|
Rosette C, Buendia-Laysa F Jr, Patkar S, et al. Anti-inflammatory and immunomodulatory activities of rifamycin SV. Int J Antimicrob Agents. 2013 Aug;42(2):182-6. PMID: 23756321.
Farrell DJ, Putnam SD, Biedenbach DJ, et al. In vitro activity and single-step mutational analysis of rifamycin SV tested against enteropathogens associated with traveler's diarrhea and Clostridium difficile. Antimicrob Agents Chemother. 2011 Mar;55(3):992-6. PMID: 21149623.
Campbell EA, Korzheva N, Mustaev A, et al. Structural mechanism for rifampicin inhibition of bacterial rna polymerase. Cell. 2001 Mar 23;104(6):901-12. PMID: 11290327.
