RufloxacinisafluoroquinoloneantibioticthatexhibitsantibacterialactivityagainstbothgramnegativeandgrampositivebacteriasuchasEscherichiaandHelicobacter.RufloxacininhibitstopoisomeraseIVandDNAgyrase.UnderUVexposure,rufloxacininducestypeIIguanineoxidation,increasingDNAbaseoxidationanddisplayingmutagenic/carcinogenicpotential.
| CasNo. | 106017-08-7 |
|---|---|
| Purity | ≥98% |
| Formula | C17H18FN3O3S•HCl |
| FormulaWt. | 399.87 |
| ChemicalName | 9-Fluro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol[1,2,3-de]-1,4-benzothiazine-6-carboxylicacidhydrochloride |
| Synonym | Qari;Monos;Tebraxin |
| MeltingPoint | 322-324°C |
| Appearance | Slightlyyellow-greencrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | R8122MSDSPDF |
|---|---|
| InfoSheet | R8122InfoSheetPDF |
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BelvedereA,BoscáF,CatalfoA,etal.TypeIIguanineoxidationphotoinducedbytheantibacterialfluoroquinoloneRufloxacininisolatedDNAandin2"-deoxyguanosine.ChemResToxicol.2002Sep;15(9):1142-9.PMID:12230407.
MontanariMP,PrennaM,MingoiaM,etal.Invitroantibacterialactivityoftrovafloxacinandfiveotherfluoroquinolones.Chemotherapy.1998Mar-Apr;44(2):85-93.PMID:9551237.
