Description
S-(N-Phenylbutylthiocarbamoyl)-glutathione(PBITC)isaconjugateofphenylbutylisothiocyanateandglutathione.IsothiocyanatesaretypicallyfoundinplantsoftheBrassicaceaefamily,includingbroccoli,cabbage,andrADIsh.Isothiocyanatesarebestknownfortheirantioxidative,anticancerchemotherapeutic,chemopreventive,anti-angiogenic,andantibioticproperties.Invitro,PBITCincreasescaspase3activityandcleavageofpoly(ADP)-ribosepolymerase(PARP),inducingcaspase-mediatedapoptosis.ThiscompounddecreasesoxidationofcarcinogenNNKandincreasesactivityofNADPH:quinoneoxidoreductaseandglutathione-S-transferaseinvitroandinvivo.
References
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YuR,MandlekarS,HarveyKJ,etal.Chemopreventiveisothiocyanatesinduceapoptosisandcaspase-3-likeproteaseactivity.CancerRes.1998Feb1;58(3):402-8.PMID:9458080.
GuoZ,SmithTJ,WangE,etal.Structure-activityrelationshipsofarylalkylisothiocyanatesfortheinhibitionof4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonemetabolismandthemodulationofxenobiotic-metabolizingenzymesinratsandmice.Carcinogenesis.1993Jun;14(6):1167-73.PMID:8508504.
