Sedanolide is a phthalide found in celery seeds that exhibits anti-inflammatory, antifungal, anti-parasitic, and nematocidal activities. Sedanolide inhibits COX-1 and COX-2 as well as topoisomerase I and topoisomerase II in vitro. Sedanolide displays antimicrobial efficacy against Aedes, Caenorhabditis, Candida, Drosophila, and Panagrellus.
| Cas No. | 6415-59-4 |
|---|---|
| Purity | ≥98% |
| Formula | C12H18O2 |
| Formula Wt. | 194.13 |
| Chemical Name | 3-Butyl-3α,4,5,6-tetrahydro-1(3H)-isobenzofuranone |
| IUPAC Name | 3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one |
| Synonym | Neocnidilide |
| Melting Point | 30-31°C |
| Solubility | Soluble in acetonitrile, ethanol, and methanol. |
| Appearance | White solid |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | S1612 MSDS PDF |
|---|---|
| Info Sheet | S1612 Info Sheet PDF |
Tsukamoto T, Ishikawa Y, Miyazawa M. Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster. J Agric Food Chem. 2005 Jul 13;53(14):5549-53. PMID: 15998112.
Jiao XZ, Xie P, Zu LS, et al. Study of stereoselective synthesis of (+/-)-neocnidilide. J Asian Nat Prod Res. 2003 Sep;5(3):165-9. PMID: 12931848.
Momin RA, Nair MG. Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds. Phytomedicine. 2002 May;9(4):312-8. PMID: 12120812.
Momin RA, Nair MG. Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds. J Agric Food Chem. 2001 Jan;49(1):142-5. PMID: 11305251.
