Sparfloxacinisafluoroquinoloneantibioticthatisclinicallyusedtotreatrespiratoryinfections;itdisplaysantibacterialefficacybyinhibitingDNAgyraseandtopoisomeraseIV.Gold(III)-chelatedsparfloxacininhibitsproliferationoflymphoma,leukemia,melanoma,andlungcancercells,displayinganticanceractivity.
| CasNo. | 110871-86-8 |
|---|---|
| Purity | ≥98% |
| Formula | C19H22F2N4O3 |
| FormulaWt. | 392.40g/mol |
| ChemicalName | rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylicacid |
| IUPACName | 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylicacid |
| Synonym | Zagam;Spara |
| MeltingPoint | 266-269°C |
| Solubility | Solubleinalcoholandchloroform.Water(0.11g/100ml) |
| Appearance | Yellowcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | S6000MSDSPDF |
|---|---|
| InfoSheet | S6000InfoSheetPDF |
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HardingI,SimpsonI.Fluoroquinolones:isthereadifferentmechanismofactionandresistanceagainstStreptococcuspneumoniae?JChemother.2000Oct;12Suppl4:7-15.PMID:11131958.
SchentagJJ.Sparfloxacin:areview.ClinTher.2000Apr;22(4):372-87;PMID:10823360.
