Sparfloxacin is a fluoroquinolone antibiotic that is clinically used to treat respiratory infections; it displays antibacterial efficacy by inhibiting DNA gyrase and topoisomerase IV. Gold(III)-chelated sparfloxacin inhibits proliferation of lymphoma, leukemia, melanoma, and lung cancer cells, displaying anticancer activity.
| Cas No. | 110871-86-8 |
|---|---|
| Purity | ≥98% |
| Formula | C19H22F2N4O3 |
| Formula Wt. | 392.40 g/mol |
| Chemical Name | rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3- quinolinecarboxylic acid |
| IUPAC Name | 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid |
| Synonym | Zagam; Spara |
| Melting Point | 266-269°C |
| Solubility | Soluble in alcohol and chloroform. Water(0.11 g/100 ml) |
| Appearance | Yellow crystalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | S6000 MSDS PDF |
|---|---|
| Info Sheet | S6000 Info Sheet PDF |
Gouvea LR, Garcia LS, Lachter DR, et al. Atypical fluoroquinolone gold(III) chelates as potential anticancer agents: relevance of DNA and protein interactions for their mechanism of action. Eur J Med Chem. 2012 Sep;55:67-73. PMID: 22835721.
Harding I, Simpson I. Fluoroquinolones: is there a different mechanism of action and resistance against Streptococcus pneumoniae? J Chemother. 2000 Oct;12 Suppl 4:7-15. PMID: 11131958.
Schentag JJ. Sparfloxacin: a review. Clin Ther. 2000 Apr;22(4):372-87; PMID: 10823360.
