Description
BeauvericinisacyclichexadepsipeptidemycotoxininitiallyproducedbyspeciesofCordyceps.Beauvericinexhibitspro-oxidativeandanticanceractivities.Incolonadenocarcinomacells,beauvericininducesoxidativestressbyincreasingROSlevelsanddecreasingglutathionelevelsandalsoinducesmitochondria-dependentapoptosisbydecreasingthemitochondrialmembranepotential.Innon-smallcelllungcancer(NSCLC)cells,beauvericinupregulatesBax,Bak,andp-Bad,downregulatesp-Bcl-2,activatescaspase3,andincreasesreleaseofcytochromec,resultinginapoptosisandcelldeath.Additionally,thiscompoundstimulatesinfluxofCa2+intocells.
References
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