Description
Cafestolisaditerpeneinitiallyfoundinbrewed,unfilteredcoffeethatexhibitsanti-angiogenic,anticancer,chemopreventive,neuromodulatory,anti-inflammatory,andhyperlipidemicactivities.Cafestolinhibitsproliferation,migration,andtubeformationinvitro,potentiallythroughdecreasingphosphorylationofFAKandAkt.Inrenalcarcinomacells,cafestolinducesG1phasecellcyclearrestandapoptosis,decreasesthemitochondrialmembranepotential,increasesactivationofcaspase3,downregulatesexpressionofBcl-2,Bcl-cl,Mcl-1,andFLIP,suppressesAktpathwaysignaling,andinhibitscellularproliferation.Inothercellularmodels,cafestoldecreasesaflatoxinB1-inducedDNAadductformationandincreaseslevelsofglutathione-S-transferase.Additionally,cafestolactivatesNrf2anddisplaysprotectivebenefitinmodelsofParkinson’sdisease.InLPS-stimulatedmacrophages,thiscompoundinhibitsERK2andMEK1anddecreasesproductionofCOX-2andprostaglandinE2(PGE2).Invivo,cafestolupregulatesexpressionofgenesinvolvedincholesterolhomeostasisbyactingasanagoNISTatthefarnesoidXreceptor(FXR)andpregnaneXreceptor(PXR).
References
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