Description
Camptothecinisaquinolonealkaloidprecursorofirinotecan;itisoriginallyproducedbyCamptotheca.Camptothecinexhibitsanticancerchemotherapeuticactivity,inhibitingtopoisomeraseIandinducingdouble-strandedDNAbreaks.Camptothecinisextremelycytotoxicandonlyitsderivativesareclinicallyusedaschemotherapeutics.
References
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RedinboMR,StewartL,KuhnP,etal.CrystalstructuresofhumantopoisomeraseIincovalentandnoncovalentcomplexeswithDNA.Science.1998Mar6;279(5356):1504-13.PMID:9488644.