Description
SinomenineisanalkaloidfoundinSinomeniumthatexhibitsanalgesic,neuroprotective,anti-inflammatory,immunomodulatory,anti-allergic,andanticancerchemotherapeuticactivities.Invivo,sinomenineimprovesmechanicalwithdrawalthresholdandcoldpainsensitivity.SinomeninealsodecreasesOVA-inducedallergiesinanimalmodels,loweringlevelsofIgE,IL-4,andIFN-γ.Additionally,sinomeninedecreasesproductionofCOX-2andotherpro-inflammatorycytokinesinvitro.Inanimalmodelsofcerebralischemia,sinomenineinhibitsacid-sensingioncurrentsandL-typevoltage-gatedCa2+currents,improvingrecoveryanddecreasinginfarctionvolume.Thiscompoundalsoinhibitstumorgrowthandcellproliferationinmodelsofbreastcancer.
References
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