Description
This product is a snake venom found in Crotalus durrisus terrificus including several toxins that cause myalgia, muscle weakness, and rhabdomyolysis. Crotoxin acts on N-type and P/Q-type Ca2+ channels to induce glutamate release and crotamine induces acetylcholine (ACh) and DA release. Crotoxin also potentiates activity at L-type Ca2+ channels. Gyrotoxin is a serine protease with thrombin-like activity. Together, these toxins may induce paralysis, acting as a neuromuscular junction (NMJ) blocker.
References
Bucaretchi F, De Capitani EM, Hyslop S, et al. Compartment syndrome after South American rattlesnake (Crotalus durissus terrificus) envenomation. Clin Toxicol (Phila). 2014 Jul;52(6):639-41. PMID: 24940645.
Vargas LS, Lara MV, Gonçalves R, et al. The intrahippocampal infusion of crotamine from Crotalus durissus terrificus venom enhances memory persistence in rats. Toxicon. 2014 Jul;85:52-8. PMID: 24813333.
Lomeo Rda S, Gonçalves AP, Silva CN, et al. Crotoxin from Crotalus durissus terrificus snake venom induces the release of glutamate from cerebrocortical synaptosomes via N and P/Q calcium channels. Toxicon. 2014 Jul;85:5-16. PMID: 24751366.
Yonamine CM, Kondo MY, Nering MB, et al. Enzyme specificity and effects of gyroxin, a serine protease from the venom of the South American rattlesnake Crotalus durissus terrificus, on protease-activated receptors. Toxicon. 2014 Mar;79:64-71. PMID: 24412460.
Ribeiro Gde B, Almeida HC, Velarde DT, et al. Study of crotoxin on the induction of paralysis in extraocular muscle in animal model. Arq Bras Oftalmol. 2012 Oct;75(5):307-12. PMID: 23471322.
