Description
Sterigmatocystin is a mutagenic and carcinogenic mycotoxin initially produced by species of Aspergillus. Sterigmatocystin is a precursor of aflatoxin B1. In vitro, this compound activates ATM, p53, and Chk2 and damages DNA, inducing G2 phase cell cycle arrest; this mechanism may also involve PI3K/Akt/mTOR signaling. In vivo, chronic administration of sterigmatocystin decreases levels of glutathione, ascorbic acid, and α-tocopherol and increases levels of ROS, increasing lipid peroxidation.
References
Zhang D, Cui Y, Shen H, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8(5):e65044. PMID: 23705030.
Xing X, Wang J, Xing LX, et al. Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells. Mol Nutr Food Res. 2011 May;55(5):749-60. PMID: 21287681.
Delgado-Virgen F, Guzman-de-Peña D. Mechanism of Sterigmatocystin Biosynthesis Regulation by pH in Aspergillus nidulans. Braz J Microbiol. 2009 Oct;40(4):933-42. PMID: 24031444.
Sivakumar V, Thanislass J, Niranjali S, et al. Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity. Hum Exp Toxicol. 2001 Aug;20(8):398-403. PMID: 11727790.
