T2 triol is a Fusarium trichothecene mycotoxin. In vitro, this compound displays significant cytotoxic activity, inducing breakdown of polyribosomes and inhibiting polypeptide chain elongation in eukaryotes. Additionally, T2 triol exhibits cytotoxicity in Jurkat T cells. This mycotoxin was initially produced by mycoplasma in barley, maize, oats, and other livestock feed grains.
| Cas No. | 34114-98-2 |
|---|---|
| Purity | ≥97%, TLC |
| Formula | C20H30O7 |
| Formula Wt. | 382.45 |
| Chemical Name | 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 8-isovalerate 3-alpha,4-beta,15-Trihydroxy-8-alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene |
| Synonym | T2 toxin triol |
| Melting Point | 162°C |
| Solubility | DMSO, Dichloromethane, methanol. Slightly soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | T0004 Info Sheet PDF |
|---|
Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.
Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.
Edwards SG. Fusarium mycotoxin content of UK organic and conventional oats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jul;26(7):1063-9. PMID: 19680981.
