LKT/ROSMARINIC ACID/R5874/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/ROSMARINIC ACID/R5874/25 mg

LKT/ROSMARINIC ACID/R5874/25 mg

商品编号： R5874-25mg

品牌： lktlabs

市场价： ¥1800.00

美元价： 1080.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDR5874

CasNo.20283-92-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Rosemarinicacidisacaffeicacidesterfoundinmanyplants,includingMelissa,Salvia,Ocimum,Rosmarinus,andOriganum.Rosemarinicacidexhibitsantidepressant,neuroprotective,anti-inflammatory,anti-allergic,anti-angiogenic,anti-fibrotic,andchemopreventiveactivities.RosemarinicacidinhibitsGABAtransaminaseanddecreasesimmobilitytimeinanimalsundergoingtheforcedswimtest.Additionally,rosemarinicacidinhibitsaggregationofamyloid-β(Aβ)peptides,delayingprogressionofAlzheimer’sdiseaseinvivo.InanimalmodelsofOVA-inducedallergy,rosemarinicaciddecreaseslevelsofIgE,IL-6,IL-1β,andTNF-α,preventsexpressionofCOX-2,andsuppressesinfiltrationbymastcellsandeosinophils.RosemarinicacidalsoinhibitstheformationofDMBA-inducedoraltumorsinanimalmodels.Thiscompoundinhibitstheproliferationofhepaticstellatecells,decreasinglevelsofα-SMA,CTGF,andTGF-β1andpreventingCCL4-inducedhepaticfibrosis.RosemarinicacidalsoinhibitsFyn,aSrcfamilykinaseinvolvedinT-cellsignaling.Invitro,rosemarinicaciddecreaseslevelsofROS,VEGF,andIL-8,suppressingcellularproliferation,migration,adhesion,andtubeformation.

ProductInfo

CasNo.	20283-92-5
Purity	≥98%
Formula	C₁₈H₁₆O₈
FormulaWt.	360.31
ChemicalName	3,4-Dihydroxycinnamicacid2-esterwith3-(3,4-dihydroxy-phenyl)lacticacid
IUPACName	3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoicacidInChI:InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+
Synonym	Rosemaryacid
MeltingPoint	171-175°C
Solubility	SolubleinDMSO,ethanol,dimethylformamide,orPBS.

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	R5874InfoSheetPDF

References

AiroldiC,SironiE,DiasC,etal.NaturalcompoundsagainstAlzheimer"sdisease:molecularrecognitionofAβ1-42peptidebySalviasclareoidesextractanditsmajorcomponent,rosmarinicacid,asinvestigatedbyNMR.ChemAsianJ.2013Mar;8(3):596-602.PMID:23303581.

AnusuyaC,ManoharanS.Antitumorinitiatingpotentialofrosmarinicacidin7,12-dimethylbenz(a)anthracene-inducedhamsterbuccalpouchcarcinogenesis.JEnvironPatholToxicolOncol.2011;30(3):199-211.PMID:22126613.

OhHA,ParkCS,AhnHJ,etal.EffectofPerillafrutescensvar.acutaKudoandrosmarinicacidonallergicinflammatoryreactions.ExpBiolMed(Maywood).2011Jan;236(1):99-106.PMID:21239739.

LiGS,JiangWL,TianJW,etal.Invitroandinvivoantifibroticeffectsofrosmarinicacidonexperimentalliverfibrosis.Phytomedicine.2010Mar;17(3-4):282-8.PMID:19524418.

ItoN,YabeT,GamoY,etal.RosmarinicacidfromPerillaeHerbaproducesanantidepressant-likeeffectinmicethroughcellproliferationinthehippocampus.BiolPharmBull.2008Jul;31(7):1376-80.PMID:18591778.

JelićD,MildnerB,KostrunS,etal.HomologymodelingofhumanFynkinasestructure:discoveryofrosmarinicacidasanewFynkinaseinhibitorandinsilicostudyofitspossIBLebindingmodes.JMedChem.2007Mar22;50(6):1090-100.PMID:17315853.

HuangSS,ZhengRL.Rosmarinicacidinhibitsangiogenesisanditsmechanismofactioninvitro.CancerLett.2006Aug8;239(2):271-80.PMID:16239062.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂