Thiscompoundisacysteine-isothiocyanateconjugatethatexhibitsantioxidative,cytoprotective,nephroprotective,andchemopreventiveactivities.Invivo,thiscompounddecreaseslungtumorformationinducedbybenzo[a]pyreneandNNK.Additionally,thisisothiocyanate(ITC)increasesexpressionandactivityofhemeoxygenase1(HO-1)anddecreasesrenaltissueapoptosisinducedbycisplatin.LikeotherITCs,thiscompoundalsoactsasaphaseIIenzymeinducer.
| CasNo. | 137915-13-0 |
|---|---|
| Purity | ≥98% |
| Formula | C13H18N2O2S2 |
| FormulaWt. | 298.42 |
| IUPACName | (2R)-2-amino-3-(3-phenylpropylcarbamothioylsulfanyl)propanoicacid |
| Synonym | S-(N-(3-Phenylpropyl)(thiocarbamoyl))-cysteine |
| MeltingPoint | 202-205°C |
| Appearance | Whitesolid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2816InfoSheetPDF |
|---|
TayemY,GreenCJ,MotterliniR,etal.Isothiocyanate-cysteineconjugatesprotectrenaltissueagainstcisplatin-inducedapoptosisviainductionofhemeoxygenase-1.PharmacolRes.2014Mar;81:1-9.PMID:24434421.
HechtSS,UpadhyayaP,WangM,etal.InhibitionoflungtumOrigenesisinA/JmicebyN-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteineandmyo-inositol,individuallyandincombination.Carcinogenesis.2002Sep;23(9):1455-61.PMID:12189187.
